I rode out from Irvine to Bakersfield about 2 days ago. It was about 300 miles round trip. You should def. make sure you do not hit any traffic and also make couple rest stops so you don't hurt your butt. Other than that, bike will be fine (you'll also see good gas mileage too), and enjoy!!
ha i rode just last sat. with the local twisties. Its was 360miles. about a quarter of that was serious twisites. so if anything is going to be a "strain" that would be more of a strain than just cruising. don't worry. keep the fluids changed and take care of other small what nots, and she'll last longer than you.